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ancient DNA, viruses, and phylogenetics
 
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PUBLICATIONS

ANCIENT DNA

Phylogeography of lions (Panthera leo) reveals a Late Pleistocene reduction in genetic diversity
Barnett R, Shapiro B, Ho SYW, Barnes I, Burger J, Yamaguchi N, Higham T, Wheeler HT, Rosendhal W, Sher AV, Baryshnikov G, Cooper A
Molecular Ecology 18: 1668-1677 (2009)

Ancient DNA typing of archaeological pig remains corroborates historical records
Haile J, Larson G, Owens K, Dobney K, Shapiro B
Journal of Archaeological Sciences (in press)

Pleistocene steppe bison (Bison priscus) partial carass from Tsiigehtchic, Northwest Territories, Canada
Zazula GD, MacKay G, Andrews TD, Shapiro B, Letts B, Brock F
Quaternary Science Reviews (in press)

Bison bone collagen isotopic values track climate fluctuations and vegetation change in Late Pleistocene and Early Holocene Northern Eurasia and North America
Richards M, Shapiro B, Ditchfield P, Cooper A
Geological Journal (in press)

Is amino acid racemization a useful tool for screening for ancient DNA in bone?
Collins MJ, Penkman KEH, Rohalnd N, Shapiro B, Dobberstein RC, Rotz-Timme A, Hofretier M
Proceedings of the Royal Society of London - Series B 276: 2971-2977 (2009) pre-publication proof

The Late Pleistocene distribution of vicuñas (Vicugna vicugna) and the “extinction” of the gracile llama (Lama gracilis): New molecular data
Weinstock J. Shapiro B, Prieto A, Martin JC, Gonzáles BA, Gilbert MPT, Willerslev E
Quaternary Science Reviews 28: 15-16 (2009)

Accommodating the effect of ancient DNA damage on inferences of demographic histories
Rambaut A, Ho SYW, Drummond AJ, Shapiro B
Molecular Biology and Evolution 26: 245-248 (2009) pdf

Mid-Holocene vertebrate bone Concentration-Lagerstätte on oceanic island Mauritius provides a window into the ecosystem of the dodo (Raphus cucullatus)
Rijsdijk KF, Hume JP, Bunnik F, Florens V, Baider C, Shapiro B, van der Plicht J, Janoo A, Griffiths O, van den Hoek Ostende LW, Cremer H, Vernimmen T, De Louw P, Bholah A, Saumtally S, Porch N, Haile J, Buckley M, Collins MC, Gittenberger E
Quaternary Science Reviews 28: 14-24 (2009) pdf

Engineered polymerases amplify the potential of ancient DNA
Shapiro B
Trends in Biotechnology 26: 285-287 (2008) pdf

Late Pleistocene Northward-dispersing Bison antiquus from the Bighill Creek Formation, Gallelli Gravel Pit, Alberta, Canada, and the Fate of Bison occidentalis
Wilson M, Shapiro B, Hills LV
Canadian Journal of Earth Sciences 45: 827-859 (2008) abstract pdf

Correlating Bayesian date estimates with climatic events and domestication using a bovine case study
Ho SYW, Larson G, Edwards CJ, Heupink TH, Lakin KE, Holland PWH, Shapiro B
Biology Letters 274: 1377-1385 (2008) pdf

The effect of inappropriate calibration in molecular ecological studies: evidence from three case studies
Ho SYW, Saarma U, Barnett R, Haile J, Shapiro B
PLoS ONE 3: e1615 (2008) link pdf

Recovery of DNA from footprints in the snow
Dalén L, Götherström A, Shapiro B
Canadian Field Naturalist 12: 321-324 (2008) pdf

Ancient DNA analysis indicates the first English lions originated from North Africa
Barnett R, Yamaguchi N, Shapiro B, Sabin R
Contributions to Zoology 77: 7-16 (2008) pdf

Comment on "Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry"
Buckley M, Walker A, Ho SYW, Yang Y, Smith C, Ashton P, Oates JT, Cappellini E, Koon H, Penkman K, Elsworth B, Ashford D, Solazzo C, Andrews P, Strahler J, Shapiro B, Ostrom P, Gandhi H, Miller W, Raney B, Zylber MI, Gilbert MT, Prigodich RV, Ryan M, Rijsdijk KF, Janoo A, Collins MJ
Science 319:33 (2008) abstract pdf supporting material

Using ancient DNA techniques to identify the origin of an unprovenanced museum specimen, as illustrated by the identification of a 19th century lion from Amsterdam
Barnett R, Yamaguchi N, Shapiro B, Nijman VB
Contributions to Zoology 76: 87-94 (2007) abstract pdf

Genetic structure and extinction of the woolly mammoth Mammuthus primigenius (Blum.)
Barnes I, Shapiro B, Kuznetsova T, Sher A, Guthrie D, Lister A, Thomas MG
Current Biology 17: 1072-1075 (2007) abstract pdf

Bayesian estimation of sequence damage in ancient DNA
Ho SYW, Heupink, TH, Rambaut, A, Shapiro B
Molecular Biology and Evolution 24:1416-1422 (2007) abstract pdf

Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs
Edwards CJ, Bollongino R, Scheu A, Chamberlain A, Tresset A, Vigne J-D, Baird JF, Larson G, Ho SYW, Heupink TH, Shapiro B, Freeman AR, Thomas MG, Arbogast R-M, Arndt B, Bartosiewicz L, Benecke N, Budja M, Chaix L, Choyke AM, Coqueugniot E, Dohle H-J, Goldner H, Hartz S, Helmer D, Herzig B, Hongo H, Mashkour M, Ozdogan M, Pucher E, Roth G, Schade-Lindig S, Schmolcke U, Schulting RJ, Stephan E, Uerpmann H-P, Voros I, Voytek B, Bradley DG, Burger J
Proceedings of the Royal Society B 274: 1377-1385 (2007) abstract pdf

Ancient DNA chronology within sediment deposits: are paleobiological reconstructions possible and is DNA leaching a factor?
Haile J, Holdaway R, Oliver K, Bunce M, Gilbert MTP, Nielsen R, Munch K, Ho, SYW, Shapiro B, Willerslev E
Molecular Biology and Evolution 24: 982-989 (2007) abstract pdf

No proof that typhoid caused the Plague of Athens
Shapiro B, Rambaut A, Gilbert MTP
International Journal of Infectious Disease 10:334-335 (2006) abstract

Metagenomics to paleogenomics: large scale sequencing of mammoth DNA
Poinar HN, Schwartz C, Qi J, Shapiro B, MacPhee RD, Biogues B, Tikhonov A, Huson D, Tonsho LP, Auch A, Rampp M, Miller W, Schuster SC
Science 311: 392-394 (2006) abstract pdf

Bayesian coalescent inference of past population dynamics from molecular sequences
Drummond AJ, Pybus OG, Shapiro B, Rambaut A
Molecular Biology and Evolution 22: 1185-1192 (2005) full text

Post-mortem DNA damage hotspots in Bison (Bison bison and B. bonasus) provide supporting evidence for mutational hotspots in human mitochondria
Gilbert MTP, Shapiro B, Drummond A, Cooper A
Journal of Archaeological Sciences 32:1053-1060 (2005) abstract

Ancient DNA provides new insights into the evolutionary history of New Zealand’s extinct giant eagle
Bunce M, Szulkin M, Lerner HRL, Barnes I, Shapiro B, Cooper A, Holdaway RN
PLoS Biology 3(1) e20 (2005) abstract pdf

Rise and fall of the Beringian steppe bison
Shapiro B, Drummond AJ, Rambaut A, Wilson MC, Matheus P, Sher AV, Pybus OG, Gilbert MTP, Barnes I, Binladen J, Willerslev E, Hansen A, Baryshnikov GF, Burns JA, Davydov S, Driver JC, Froese D, Harington CR, Keddie G, Kosintsev P, Kunz ML, Martin LD, Stephenson RO, Storer J, Tedford R, Zimov S, Cooper A
Science 306: 1561-1565 (2004) abstract pdf

Ancient mitochondrial DNA from hair
Gilbert MTP, Wilson AS, Bunce M, Hansen AJ, Willerslev E, Shapiro B, Higham TFG, Richards MP, O’Connell TC, Tobin DJ, Janaway RC, Cooper A
Current Biology 14: R463-464 (2004) abstract

Beringia as an Ice Age genetic museum
Shapiro B, Cooper A
Quaternary Research 60 (1): 94-100 (2003) abstract

Diverse plant and animal genetic records from Holocene and Pleistocene sediments
Willerslev E, Hansen AJ, Binladen J, Brand TB, Gilbert MTP, Shapiro B, Bunce M, Wiuf C, Gilichinsky DA, Cooper A
Science 300: 791-795 (2003) abstract pdf

Exceptional preservation in bison bones older than 55 ka demonstrated by protein and DNA sequences
Nielsen-Marsh, CM, Ostrom PH, Gandhi H, Shapiro B, Cooper A, Collins MJ

Geology 30: 1099-1102 (2002) pdf

Molecular phylogeny and evolution of the extinct bovid Myotragus balearicus
Lalueza-Fox, C, Shapiro B, Bover P, Alcover JA, Bertranpetit J
Molecular Phylogenetics and Evolution 25 (3): 501-510 (2002) abstract

Flight of the Dodo
Shapiro B, Sibthorpe D, Austin J, Wragg G, Lee PLM, Bininda-Emonds ORP, and Cooper A
Science 295: 1683 (2002) abstract pdf

Dynamics of mammal population extinctions in eastern Beringia during the last glaciation
Barnes I, Matheus P, Shapiro B, Jensen D, Cooper A
Science 295: 2267-2270 (2002) abstract pdf

BOOK CHAPTERS

Using DNA to investigate human evolution
Shapiro B, Gilbert MTP, Barnes I
In H Schutkowski, Ed. Between Biology and Culture. Cambridge University Press (in press).

VIRUS EVOLUTION

Insights into the evolutionary history of an emerging livestock pathogen: Porcine Circovirus 2
Ramsden C, Charleston MA, Duffy S, Shapiro B, Holmes EC
Journal of Virology (in press)

Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients
Kapoor A, Shapiro B, Shafer RW, Rhee S-Y, Delwart EL

Retrovirology 5: 7 (2008) full text

Estimating the relative contribution of dNTP pool imbalance and APOBEC3G/3F editing to HIV evolution in vivo
Deforche K, Camacho R, Laethem KV, Shapiro B, Moreau Y, Rambaut A, Vandamme A-M, Lemey P
Journal of Computational Biology 14:1105-14 (2007) abstract

Recombination is confounding the early evolutionary history of HIV-1: subtype G is a circulating recombinant form
Abecasis AB, Lemey P, Vidal N, de Oliveira T, Peeters M, Camacho R, Shapiro B, Rambaut A, Vandamme A-M
Journal of Virology 81: 8543-51 (2007) abstract

Ancient papillomavirus-host co-speciation in Felidae
Rector A, Lemey P, Tachezy R, Mostmans S, Ghim S-G, Van Doorslaer K, Roelke M, Bush M, Montali RJ, Joslin J, Burk RD, Jenson AB, Sundberg JP, Shapiro B, Van Ranst M
Genome Biology 8:R57 (2007) full text

Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics
Lemey P. Kosakovsky-Pond SL, Drummond AJ, Pybus OG, Shapiro B, Barroso H, Taveira N, Rambaut A
PLoS Computational Biology 3:e29 (2007) full text

A phylogenetic method to detect positive epistasis and its application to RNA virus evolution
Shapiro B, Drummond AJ, Rambaut A, Pybus OJ, Holmes EC
Molecular Biology and Evolution 23: 1724-1730 (2006) full text

PHYLOGENETICS and MOLECULAR EVOLUTION

Accommodating the effect of ancient DNA damage on inferences of demographic histories
Rambaut A, Ho SYW, Drummond AJ, Shapiro B
Molecular Biology and Evolution (in press)

The effect of inappropriate calibration in molecular ecological studies: evidence from three case studies
Ho SYW, Saarma U, Barnett R, Haile J, Shapiro B
PLoS ONE 3: e1615 (2008)

Evidence for time dependency of molecular rate estimates
Ho SYW, Shapiro B, Phillips MJ, Cooper A, Drummond AJ
Systematic Biology 56: 515-522 (2007) pdf

Bayesian estimation of sequence damage in ancient DNA
Ho SYW, Heupink, TH, Rambaut, A, Shapiro B
Molecular Biology and Evolution 24:1416-1422 (2007) abstract pdf

Choosing appropriate substitution models for the phylogenetic analysis of protein-coding sequences
Shapiro B, Rambaut A, Drummond AJ
Molecular Biology and Evolution 23: 7-9 (2006) full text

Bayesian coalescent inference of past population dynamics from molecular sequences
Drummond AJ, Pybus OG, Shapiro B, Rambaut A
Molecular Biology and Evolution 22: 1185-1192 (2005) full text

CONSERVATION BIOLOGY

Is the endangered Grevy’s zebra threatened by hybridization?
Cordingly JE, Sundarisan SR, Fischhoff IR, Shapiro B, Ruskey J, Rubenstein DI
Animal Conservation (in press) abstract pdf

BOOK CHAPTERS

Natural selection and adaptation of molecular sequences
Pybus OG, Shapiro B
In Lemey P, Salemi M, Vandamme A-M, Eds., The Phylogenetic Handbook: A Practical Approach to Phylogenetic Analysis and Hypothesis Testing (2nd Edition). Cambridge University Press (in press).

Using DNA to investigate human evolution
Shapiro B, Gilbert MTP, Barnes I
In Schutkowski H, Ed., Between Biology and Culture. Cambridge University Press (2008)

Ancient DNA from vertebrate fossils
Barnett R, Shapiro B, Barnes I
In Elias SA, Ed., Encyclopedia of Quaternary Science. Elsevier (2006)


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ANCIENT DNA
Extracting and characterizing DNA from fossil remains.

VIRUS EVOLUTION
Understanding the evolutionary constraints underpinning diversity and evolution in RNA viruses.

PHYLOGENETICS and MOLECULAR EVOLUTION
Investigating patterns and processes in molecular evolution.

CONSERVATION BIOLOGY
Applications of molecular phylogenetics and evolution to problems in conservation research..