Molecular Evolution and Phylogenetics

	Sudhir Kumar Institute of Molecular Evolutionary Genetics 328 Mueller Laboratory The Pennsylvania State University University Park, PA 16802 Current Address: Director Center for Evolutionary Functional Genomics The Biodesign Institute BDA-240 Arizona State University Tempe, AZ 85287-5301 E-mail: s.kumar@asu.edu Sudhir Kumar Homepage

Introduction The following analyses can be conducted with this program. 1. Comparison of three alternative phylogenetic trees for four monophyletic clusters of sequences (four-cluster analysis; Rzhetsky, Kumar & Nei 1995). 2. Examination of the null hypothesis that an interior branch length is significantly greater than zero (interior-branch test; Rzhetsky & Nei 1992). 3. Estimation of average pairwise distances (and standard errors) within and between clusters of sequences. 4. Relative rate tests and the computation of the time of divergence.

Installation PHYLTST.exe is a self extracting file. This compressed module contains the executables and examples for the program It can be used in DOS, and Windows 3.1, 95, and NT in the DOS box. If you have any problems in correctly installing this program in your directory (or fetching it), please write to the above address.